The Synthesis of a Two-Photon Fluorescence Labelling Probe and its Immunochromatographic Strip for Rapid Diagnosis of COVID-19

A two-photon fluorescence labelling probe (LP) was synthesised, and LP-Ag obtained by LP the N-protein antigen (Ag) of COVID-19. made into an immunochromatographic strip. When a blood sample added to hole test card, it would move forward along nitrocellulose (NC) film. If contained IgM, IgM bound formed M line with coated mouse anti-human antibody, giving positive response presence The sensitivity, specificity, accuracy strip based on compared those nucleic acid detection method colloidal gold method, proving be much simpler than which can greatly shorten period, more stable overcome uncertainty. used image lung tissue COVID-19 microscopy (TFM).